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Humoral immunity in stage I mycosis fungoides: an increased incidence of lymphocytotoxic antibodies
Author(s) -
SCHOCKET ALAN L.,
HUFF J. CLARK,
CARR RONALD I.,
NORRIS DAVID A.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00358.x
Subject(s) - mycosis fungoides , immunology , anti nuclear antibody , rheumatoid factor , antibody , incidence (geometry) , immune system , antigen , medicine , autoantibody , humoral immunity , lymphoma , physics , optics
SUMMARY Thirteen patients with stage I mycosis fungoides (MF) were studied for the presence of circulating autoantibodies including cold‐reactive lymphocytotoxic antibodies (LCA), antinuc‐lear antibodies and rheumatoid factor antibodies to common food antigens, bovine gamma globulin and casein; and immune complexes as measured by cryoglobulins and I 125 Clq binding. A significantly increased incidence (11/13) of LCA was found in the MF patients, and this may be related to the alterations in subpopulations of T cells seen in these patients. No significant increase in any other test was noted. There was no evidence of a diffuse hyperactivity of the humoral immune system as seen in systemic lupus erythematosus, which has a similar imbalance of T cell subpopulations.