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Assessment of anti‐stratum corneum antibody titres in pustulosis palmaris et plantaris
Author(s) -
DANNO K.,
OKAMOTO H.,
AND S. IMAMURA,
OFUJI S.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00336.x
Subject(s) - stratum corneum , pustulosis , dermatology , medicine , immunology , pathology , osteitis , osteomyelitis
SUMMARY Titres of anti‐stratum corneum (SC) antibodies, determined by an indirect immunofluores‐cence (IF) technique, were significantly higher on average in pustulosis palmaris et plantaris (PPP) and pompholyx than in normal controls. By a complement IF technique, the antibodies fixed complement (C 3 ) in high title in PPP, but to a much lesser degree in pompholyx and normal controls. Direct IF microscopy studies showed the deposition of IgG and C 3 in the SC in some of the biopsy specimens of the pustular lesions. These findings suggest that in PPP anti‐SC antibodies may be involved at least in part in activation of the complement system and the subsequent accumulation of polymorphonuclear leukocytes.