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The effect of the antiandrogen IIα‐hydroxyprogesterone on sebum production and cholesterol concentration of sebum
Author(s) -
TAMM J.,
SECKELMANN M.,
VOLKWEIN U.,
LUDWIG E.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00291.x
Subject(s) - medicine , library science , history , computer science
SUMMARY IIα‐Hydroxyprogesterone, a synthetic antiandrogen of low toxicity, was applied topically. In short‐term experiments the sebum production of the forehead in normal male subjects was reduced significantly. The cholesterol concentration of sebum decreased to a greater extent. In long‐term studies in patients with seborrhoea and male‐pattern alopecia, the steroid caused a marked and constant reduction of greasiness of the hair. In this group also, the cholesterol concentration of the sebvim obtained from scalp hair decreased more markedly than total sebum production. Possible effects of IIα‐hydroxyprogesterone on androgenic alopecia are discussed.