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Modulation of adenosine 3′,5′‐cyclic monophosphate‐dependent protein kinase in skin
Author(s) -
HOLIAN O.,
KUMAR R.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00286.x
Subject(s) - adenosine , protein kinase a , modulation (music) , cyclic adenosine monophosphate , adenosine monophosphate , chemistry , medicine , kinase , endocrinology , biochemistry , physics , receptor , acoustics
SUMMARY Incubation in vitro of full‐thickness guinea‐pig skin with epinephrine or histamine resulted in the formation of adenosine 3′,5′‐cyclic monophosphate (cyclic AMP) and increase in the cyclic AMP‐dependent protein kinase activity ratio. The effect was dose‐dependent between 10 −5 and 10 −3 M concentration of the agents. Histamine antagonists, diphenhydramine (H 1 ) and cimetidine (H 2 ) prevented stimulation by histamine in a dose‐dependent manner suggesting the presence of both types of receptors in full‐thickness skin. Cyclic AMP accumulation with a concomitant increase in protein kinase activity denotes that phosphoproteins may have an important role in skin biology.