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Hepatitis B surface antigen deposition in the blood vessel walls of urticarial lesions in acute hepatitis B
Author(s) -
NEUMANN H.A.M.,
BERRETTY P.J.M.,
FOLMER S.C.C. REINDERS,
CORMANE R.H.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb15307.x
Subject(s) - medicine , viral hepatitis , hepatitis , hepatitis b , prodrome , immunology , immune system , antigen , serum sickness , immunofluorescence , pathology , antibody , psychosis , psychiatry
SUMMARY Urticaria is known to occur in the pre‐icteric phase of acute viral hepatitis. Often such urticaria is a symptom of a serum sickness‐like syndrome which can be a prodrome of viral hepatitis. Immune complexes are thought to be pathogenetic in this condition. In this paper we present two patients with a serum sickness‐like syndrome, urticaria and hepatitis B. By immunofluorescence techniques Hepatitis B surface antigen, C Iq and C 3 could be demonstrated in the blood vessels of the superficial dermis. These findings are consistent with the immune complex hypothesis.