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Reduction of increased polyamine levels in psoriatic lesions by retinoid and PUVA treatments
Author(s) -
LAUHARANTA JORMA,
KOUSA MERJA,
KAPYAHO KIRSTI,
LINNAMAA KIRSTI,
MUSTAKALLIO KIMMO
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb01284.x
Subject(s) - putrescine , spermidine , etretinate , retinoid , spermine , ornithine decarboxylase , polyamine , chemistry , dermatology , psoriasis , pharmacology , medicine , endocrinology , biochemistry , retinoic acid , enzyme , gene
SUMMARY Treatment with an oral aromatie retinoid (etretinate) and with PUVA significantly reduced the elevated levels of putrescine, spermidine and spermlne in psoriatic lesions. Both treatments also significantly reduced the spermidine/spermine ratio, which is considered to be an indicator of proliferation activity. Although both regimens produced a roughly parallel reduction of epidermal polyamines the initial fall of putrescine was much more rapid in patients receiving retinoid. This may indicate that one of the primary targets of retinoids could be ornithine deearboxylase.