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The influence of Tigason’ (Ro 10–9359) on the serum lipoproteins in man
Author(s) -
MICHAËLSSON G.,
BERGQVIST A.,
VAHLQUIST A.,
VESSBY B.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb01206.x
Subject(s) - medicine , dermatology
SUMMARY Eight patients with psoriasis or Darier's disease were studied during 1–3 months of‘Tigason’ treatment (O.7–O.8 mg/kg body weight). The levels of triglycerides and cholesterol in whole serum and in different lipoprotein fractions were repeatedly determined. Before treatment all lipid values were within the normal range. During treatment the values changed gradually and five of the eight patients developed pathological VLDL triglyceride concentrations. A significant increase of VLDL cholesterol and a decrease in the HDL cholesterol was also noted. Until more information is available, prolonged treatment periods with‘Tigason’ should perhaps be avoided, at least in high risk patients.