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Dermatitis herpetiformis: immune complex detection with CIq and monoclonal rheumatoid factor
Author(s) -
JORDON ROBERT E.,
TAPPEINER GERHARD,
KAHL JANE C.,
WOLFF KLAUS
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb01201.x
Subject(s) - dermatitis herpetiformis , medicine , rheumatoid factor , monoclonal , dermatology , immune system , monoclonal antibody , rheumatoid arthritis , immunology , pathology , antibody , disease
SUMMARY To determine the significance of circulating immune complexes in dermatitis herpetiformis, serum samples from thirty patients with active disease were tested by a CIq binding radioassay, while serum samples from twenty‐one of these patients were tested by a monoclonal rheumatoid factor (mRF) inhibition radioassay. By direct immunofluorescence, all patients demonstrated typical IgA deposition in dermal papillae. Using the Ci q binding assay, only seven of forty‐two serum samples had elevated Ci q binding activity, while by the mRF inhibition assay, thirteen of twenty‐five samples had elevated immune complex levels. Nine of these latter thirteen positive serum samples, however, were minimally elevated. Thus, IgG and/or IgM containing immune complexes are infrequently present, or at very low levels, in sera of patients with active dermatitis herpetiformis.