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Retinol binding protein in normal human skin and in cutaneous disorders
Author(s) -
BENOLDI D.,
MANFREDI G.,
PEZZAROSSA E.,
ALLEGRA F.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb00976.x
Subject(s) - retinol binding protein , porphyria cutanea tarda , psoriasis , retinol , dermis , human skin , medicine , endocrinology , vitamin , immunofluorescence , epidermis (zoology) , chemistry , dermatology , biology , pathology , immunology , antibody , anatomy , genetics
SUMMARY Circulating vitamin A is transported by a carrier termed retinol binding protein (RBP). Autoradiography and immunofluorescence studies showed that, in normal human skin, RBP is confined exclusively to the dermis. Following oral vitamin A loading, a large increase in dermal RBP but only a very small rise of serum RBP was found. Serum RBP was slightly decreased in eczema patients and markedly decreased in patients with porphyria cutanea tarda. Values in other dermatoses, including psoriasis, were normal.