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HLA‐DR3 in dermatitis herpetiformis
Author(s) -
PEHAMBERGER HUBERT,
HOLUBAR KARL,
MAYR WOLFGANG R.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb00956.x
Subject(s) - dermatitis herpetiformis , human leukocyte antigen , incidence (geometry) , antigen , dermatology , medicine , immunology , population , linkage disequilibrium , biology , genetics , pathology , haplotype , allele , disease , gene , physics , environmental health , optics
SUMMARY Twenty‐one patients with dermatitis herpetiformis were typed for HLA‐ABC and ‐DR determinants. The incidence of HLA‐AI, ‐B8 and ‐DR3 antigens was found to be significantly higher ( P : = 10 −3 , <10 −6 and <10 −6 , respectively) among patients with dermatitis herpetiformis than among the normal population. HLA‐DR3 was found in 85.7% of patients, HLA‐B8 in 66.7% and HLA‐A i in 61.9% only. These results indicate that HLA‐DR3 is the antigen primarily associated in dermatitis herpetiformis and the latter antigens (HLA‐A i and ‐B8) are present in increased incidence, probably due to the known linkage disequilibrium of these antigens with HLA‐DR3.