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Flow cytometry as a tool for the study of cell kinetics in skin 2. Cell kinetic data in psoriasis
Author(s) -
BAUER F.W.,
CROMBAG N.H.C.M.N.,
BOEZEMAN J.B.M.,
GROOD R.M.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb00948.x
Subject(s) - psoriasis , flow cytometry , kinetics , kinetic energy , cell , medicine , dermatology , chemistry , immunology , physics , biochemistry , quantum mechanics
SUMMARY Flow cytometry was used to measure the DNA content of epidermal keratinocytes from psoriatic patients. Gross deviations were found in the lesions and minor but significant changes in the uninvolved skin. Statistical analysis revealed that the rather large variation in the DNA distributions of the lesions was due to inter‐individual differences rather than to inter‐individual differences. The duration of the S‐phase seemed to be prolonged in the lesion, but the length of the overall cell cycle might be of the same order as that of normal skin.