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Ultraviolet light treatment delays contact sensitization to nitrogen mustard
Author(s) -
HALPRIN KENNETH M.,
COMERFORD MARY,
PRESSER STEPHEN E.,
TAYLOR J.RICHARD
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb00884.x
Subject(s) - sensitization , nitrogen mustard , ultraviolet light , ultraviolet , medicine , chemistry , dermatology , photochemistry , immunology , materials science , surgery , optoelectronics , chemotherapy , cyclophosphamide
SUMMARY Contact sensitivity to nitrogen mustard was delayed after first treating patients with u.v. light. While the number of patients becoming sensitive to nitrogen mustard after ultraviolet light exposure was not significantly different from the control, the number of patients who became sensitive in the first 30 days was significantly less than the control group. It is postulated that this delay in sensitization is due to an alteration of the patients’ epidermal Langerhans cells, produced by the u.v. light exposure.