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Dietary influences on 8‐MOP plasma levels in PUVA patients with psoriasis
Author(s) -
ROELANDTS R.,
BOVEN M.,
DEHEYN T.,
STICHELE G. VANDER,
DEGREEF H.,
DAENENS P.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb00801.x
Subject(s) - psoriasis , puva therapy , medicine , dermatology
SUMMARY To Study the effect of diet on 8‐MOP plasma levels, these levels were measured three times in twenty PUVA patients with psoriasis; while fasting, after a low‐fat breakfast, and after a fat‐rich breakfast. No significant differences were found between the maximal 8‐MOP plasma levels in the fasting condition and the levels after the low‐fat breakfast, both peaking 2 h after ingestion. After the fat‐rich breakfast, however, the 8‐MOP plasma levels were not only significantly lower at a h but also peaked later, reaching their maximum at 3–4 h after intake. The drug should therefore be given in a dietetically standardized way. This raises the question whether some cases of therapy resistance can be dietetically influenced.