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Evaluation of drug phototoxicity by photosensitization of Trichophyton mentagrophytes
Author(s) -
HORIO TAKESHI
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb00767.x
Subject(s) - phototoxicity , trichophyton , perphenazine , tolbutamide , drug , promethazine , chlorpromazine , pharmacology , chemistry , microbiology and biotechnology , in vitro , toxicology , medicine , biology , biochemistry , antifungal , insulin
SUMMARY Long wave ultraviolet radiation to suspensions of T. mentagrophytes , in the presence of photosensi tizing chemicals, resulted in death of the fungus as measured by loss in colony‐forming ability. Photosensitization could be demonstrated, with appropriate exposures and concentrations, with chlorpromazine, promethazine, perphenazine, anthracene, sulphanilamide, trimethylpsoralen, tolbutamide, tetrachlorosalicylanilide, and tribromosalicylanilide. No phorotoxicity was detected with demethylchlortetracycline and thiazides. The present system seems to be simple, reproducible, and sensitive as an in vitro screening test for the photosensitizing potential of chemicals.