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Studies on the plasma membrane of normal and psoriatic keratinocytes. 3. Uptake of labelled sugars and their incorporation into glycoconjugates
Author(s) -
ROELFZEMA H.,
BERGERS M.,
ERP P.E.J.,
GOMMANS J.M.,
MIER P.D.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb00749.x
Subject(s) - glycoconjugate , psoriasis , in vitro , epidermis (zoology) , fucose , lesion , chemistry , biochemistry , metabolism , dermatology , biology , pathology , glycoprotein , medicine , anatomy
SUMMARY We report the uptake of four labelled sugars by keratinocytes isolated from normal epidermis, psoriatic ‘uninvolved’ skin and psoriatic lesions. Our findings include the following:1 The rate of uptake of all sugars by the psoriatic lesion is increased. 2 This abnormally high uptake diminishes dramatically during 22 h incubation in vitro . 3 There is a striking abnormality in the metabolism of fucose by psoriatic keratinocytes; our data suggest an increased rate of incorporation of fucose into glycoconjugates.