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The influence of ultraviolet radiation on allergic contact dermatitis in the guinea‐pig. II. Psoralen/UVA radiation
Author(s) -
MORISON WARWICK L.,
PARRISH JOHN A.,
WOEHLER MICHAEL E.,
BLOCH KURT J.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb00040.x
Subject(s) - medicine , medical school , general hospital , dermatology , atopic dermatitis , library science , art history , family medicine , history , medical education , computer science
Summary Guinea‐pigs were sensitized by percutaneous application of dinitrochlorobenzene and exposed to UVA (320–400 nm) radiation following systemic administration of methoxsalen. This treatment diminished the response to an elicitation dose of the hapten administered 14 days later within the site of irradiation. The site of elicitation of the allergic response had to be included in the field of exposure, and reduction of the allergic response was observed only when the exposure to radiation was commenced at the time of induction of contact allergy. Established contact skin sensitivity was not affected by radiation.