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The influence of ultraviolet radiation on allergic contact dermatitis in the guinea‐pig. I. UVB radiation
Author(s) -
MORISON WARWICK L.,
PARRISH JOHN A.,
WOEHLER MICHAEL E.,
BLOCH KURT J.
Publication year - 1981
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1981.tb00039.x
Subject(s) - allergic contact dermatitis , ultraviolet radiation , dermatology , medicine , radiation , hapten , contact dermatitis , immunology , chemistry , allergy , radiochemistry , optics , antigen , physics
SUMMARY Guinea‐pigs were sensitized by percutaneous application of dinitrochlorobenzene and exposed to UVB (280–320 nm) radiation. The exposure to radiation diminished the response to an elicitation dose of the hapten administered 14 days later within the site of irradiation. The exposure dose of radiation required to produce this effect resulted in a marked erythemal response, but this response did not conceal the contact allergic reaction. The site of elicitation of the allergic response had to be included in the exposure field.