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Do corticosteroids prevent post‐herpetic neuralgia?
Author(s) -
KECZKES KALMAN,
BASHEER A. M.
Publication year - 1980
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1980.tb07654.x
Subject(s) - medicine , prednisolone , carbamazepine , neuralgia , incidence (geometry) , zona , anesthesia , surgery , corticosteroid , epilepsy , viral disease , neuropathic pain , human immunodeficiency virus (hiv) , physics , psychiatry , optics , family medicine
SUMMARY Forty otherwise healthy patients over 50 years of age with early, severe painful herpes zoster were randomly allocated to two groups for treatment. Twenty patients received prednisolone 40 mg daily with gradual reduction over a period of 4 weeks, whilst the other twenty patients received carbamazepine 100 mg four times daily. Thirteen of the twenty patients (65%) in the carbamazepine treated group developed post‐herpetic neuralgia lasting up to 2 years, whilst only three of the twenty prednisolone treated patients (15%) had post‐herpetic neuralgia lasting up to 6 months only. Thus the incidence and duration of post‐herpetic neuralgia were considerably reduced in the prednisolone treated group. In neither group did disseminated zoster or other complications occur.