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Chromosome studies in mycosis fungoides
Author(s) -
VLOTEN W. A.,
PET E. A.,
GERAEDTS J. P. M.
Publication year - 1980
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1980.tb07647.x
Subject(s) - mycosis fungoides , phytohaemagglutinin , chromosome , biology , centromere , peripheral blood , pathology , disease , lymphocyte , dermatology , medicine , immunology , genetics , lymphoma , gene
SUMMARY G‐banded chromosome analysis was performed on peripheral blood lymphocytes after phytohaemagglutinin stimulation from sixteen patients with mycosis fungoides. A number of chromosome abnormalities were observed in a low proportion of blood lymphocytes in seven patients in later stages of the disease. In four patients similar marker chromosomes in multiple copies were present, some of them without a clearly visible centromere. We conclude that a correlation exists between the presence of chromosome abnormalities in circulating blood lymphocytes and the course of the disease.