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Sister chromatid exchange and chromosome aberration rates in a group of psoriatics before and after a course of PUVA treatment
Author(s) -
FAED M. J. W.,
WILLIAMSON L.,
PETERSON S.,
LAKSHMIPATHI T.,
JOHNSON B. E.,
FRAINBELL W.
Publication year - 1980
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1980.tb07247.x
Subject(s) - sister chromatids , chromosome , sister chromatid exchange , chromatid , chromosome aberration , psoriasis , puva therapy , genetics , irradiation , medicine , biology , dermatology , dna , physics , gene , nuclear physics
SUMMARY Blood was cultured and chromosome preparations were examined for sister chromatid exchanges and chromosome aberrations in eighteen patients receiving photochemotherapy with 8‐MOP and UV‐A for the treatment of psoriasis, both before starting treatment and again 6 months later. The UV‐A was administered both by means of low output (irradiance: 1.1–2.25 mW/cm 2 ) and high output (irradiance: 6.1–7.6 mW/cm 2 ) UV‐A radiation cubicles. Irrespective of the intensity of irradiation or the total dose of UV‐A administered there was no evidence of chromosome damage in lymphocytes following treatment.