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Petrolatum: interference with the oxidation of arachidonic acid
Author(s) -
PENNEYS NEAL S.,
EAGLSTEIN WILLIAM,
ZIBOH VINCENT
Publication year - 1980
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1980.tb07242.x
Subject(s) - arachidonic acid , interference (communication) , chemistry , medicine , biochemistry , computer science , telecommunications , channel (broadcasting) , enzyme
SUMMARY Microsomal preparations from petrolatum‐treated wound skin contained significantly less arachidonic acid‐dependent oxidative capacity when compared to activities in untreated wounded skin (t = 6.06, P < 0.001). Microsomes from both untreated and petrolatum‐treated wounded skin produced similar quantities of PGE 2 and PGF 2α ; however, microsomal lipoxygenase activity in petrolatum‐treated wounded skin was depressed when compared to that in untreated wounded skin. Microsomal preparations from normal pig skin treated with petrolatum oxidized arachidonic acid at a similar rate to those from untreated control skin. Increasing quantities of petrolatum progressively inhibited the synthesis of PGE 2 and PGF 2α by fetal calf skin microsomes in vitro as determined by both the oxidation of arachidonic acid and the quantification of radioactive product. Topical application of banal compounds that contain lipid substances may therefore alter the cutaneous inflammatory response by local suppression of pathways that generate hydroxy‐fatty acids, substances that are known to be chemotactic and pro‐inflammatory.