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Pagetoid reticulosis: a disease of histiocytic origin
Author(s) -
CHU A. C.,
MacDONALD D. M.
Publication year - 1980
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1980.tb06584.x
Subject(s) - pagetoid , histiocyte , pathology , epidermis (zoology) , immunohistochemistry , electron microscope , transmission electron microscopy , medicine , biology , chemistry , anatomy , materials science , physics , optics , nanotechnology
SUMMARY A patient with Pagetoid reticulosis has been investigated using standard transmission electron microscopy and an immunohistochemical technique for identifying T lymphocytes in situ in light and electron microscopy. Our results indicate that the majority of the cells in the underlying dermal infiltrate are T lymphocytes but that only very few T lymphocytes are found in the extensive epidermal infiltrate. Ultrastructurally the majority of the abnormal cells in the epidermis are of histiocytic origin.