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A method for the evaluation of the local antiandrogenic action of 5α‐reductase inhibitors on human skin
Author(s) -
VERMORKEN A. J. M.,
GOOS C. M. A. A.,
ROELOFS H. M. J.
Publication year - 1980
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1980.tb06571.x
Subject(s) - human skin , site of action , 5 alpha reductase inhibitor , pharmacology , reductase , action (physics) , enzyme , chemistry , medicine , biology , biochemistry , finasteride , physics , genetics , cancer , quantum mechanics , prostate
SUMMARY A method has been developed for the first time that allows the evaluation of the effect of therapeutic concentrations of 5α‐reductase inhibitors in human skin, without applying radioactivity to the skin. Moreover, the method makes it possible to determine whether inhibition is found only at the application site or also in other parts of the skin.