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Psoriasis and HLA‐Cw6
Author(s) -
TIILIKAINEN A.,
LASSUS A.,
KARVONEN J.,
VARTIAINEN P.,
JULIN M.
Publication year - 1980
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1980.tb05690.x
Subject(s) - psoriasis , immunology , human leukocyte antigen , major histocompatibility complex , locus (genetics) , medicine , histocompatibility , gene , dermatology , antigen , biology , genetics
SUMMARY The prevalence of histocompatibility antigen HLA‐Cw6 was 72.7% in twenty‐two patients with the guttate form and 45.9% in thirty‐seven patients with the vulgaris form of psoriasis; the difference between these figures and the prevalence (7.4%) in 462 healthy blood donors in Finland is highly significant. The previously observed excess of several HLA‐B locus genes might be secondary to their close linkage with the Cw6 gene. Hereditary factors appear more important in the guttate than in the vulgaris form of psoriasis.