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Immunological aspects of psoriasis
Author(s) -
GUILHOU JEANJACQUES,
CLOT JACQUES,
GUILLOT BERNARD,
ANDARY MONIQUE,
MEYNADIER JEAN
Publication year - 1980
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1980.tb05689.x
Subject(s) - psoriasis , medicine , dermatology , immunology
SUMMARY We investigated sixteen patients before and after 1 month of PUVA therapy (three times a week) for circulating immune complexes (CIC) and T‐cell markers. CIC were detected by the PEG‐C4 assay, using a laser nephelometry determination of polyethylene glycol (PEG, 3.5%) precipitated endogenous C4. T cells were evaluated by E rosettes, active E rosettes, anti‐HTLA serum and ox EA γ‐rosettes. This latter method investigated mainly T cells bearing Fc receptors for IgG (Ty‐cells). After 1 month of PUVA‐therapy: (a) the cutaneous lesions markedly improved; (b) the mean percentages of E rosettes, active E rosettes, and HTLA bearing cells, depressed before treatment, returned to normal; (c) CIC were found in higher amounts; (d) T γ‐cell numbers decreased simultaneously. The improvement of T‐cell levels assessed by E rosettes, active E rosettes and HTLA values was correlated with clearing of skin lesions, as previously reported by others. However, the increase of CIC during PUVA therapy, their correlation with T γ‐cell decrease, and their possible role in the pathogenic chain of psoriasis remains uncertain.