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The stratum granulosum: a contractile system
Author(s) -
SHELLEY WALTER B.,
JUHLIN LENNART
Publication year - 1980
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1980.tb05682.x
Subject(s) - stratum granulosum , contraction (grammar) , egta , epidermis (zoology) , chemistry , calcium , anatomy , biology , endocrinology , stratum corneum , genetics , organic chemistry
SUMMARY Sheets of stratum granulosum of glycerinated cow hoof epidermis showed immediate contraction on exposure to ATP in the presence of calcium. Other layers of the epidermis were unresponsive. Contraction of the stratum granulosum could be induced also by dopamine, but not by a variety of other pharmacological agents. It could be blocked by EGTA, lidocaine, or high concentrations of potassium. It is postulated that the keratohyalin granule is a contractile protein uniquely responsible for the changes observed.