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Delayed skin test reactivity to Propionibacterium acnes correlates with severity of inflammation in acne vulgaris
Author(s) -
KERSEY P.,
SUSSMAN M.,
DAHL M.
Publication year - 1980
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1980.tb01687.x
Subject(s) - propionibacterium acnes , acne , medicine , inflammation , dermatology , immunology , immune system
SUMMARY Propiontibacterium acnes is the bacterial species most consistently isolated from acne lesions. Intradermal injection of a heat‐killed suspension of P. acnes induced a delayed erythematous and often papular inflammatory reaction which was maximal after 24–48 h. This response was dose related and was probably mediated at least partly by immune mechanisms. In eighty‐one subjects with acne of varying severity the intensity of the 48 h skin test reaction was significantly related to the severity of the acne. These findings indicate that the host response to P. acnes is an important variable in determining the severity of inflammatory acne.