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Changes in proliferative activity as cells move along undulating basement membranes in stratified squamous epithelium
Author(s) -
HUME W.J.,
POTTEN C.S.
Publication year - 1980
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1980.tb01664.x
Subject(s) - basement membrane , stratified squamous epithelium , basal (medicine) , epithelium , interphase , tongue , membrane , basement , anatomy , biology , pathology , cell , chemistry , microbiology and biotechnology , medicine , endocrinology , biochemistry , geography , archaeology , insulin
SUMMARY The filiform papillae of mouse tongue provide evidence for a flow of interphase basal cells along the basement membrane. This implies that they are aligned on that structure according to age. In addition there is a decrease in proliferative potential as the basal cells age. This is probably due at least in part to a fall in growth fraction. Such a method of basal cell replacement may exist in other stratified squamous epithelia characterized by undulating basement membranes.