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The effect of H 1 and H 2 histamine antagonists on symptomatic dermographism
Author(s) -
MATTHEWS CYNTHIA N.A.,
BOSS J.M.,
WARIN R.P.,
STORARI FRANKIE
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb15293.x
Subject(s) - histamine , medicine , dermatology , pharmacology
SUMMARY In ten patients suffering from symptomatic dermographism the combined administration of chlor‐phemiramine + cimetidine produced a greater reduction in the weal and flare response provoked by a standardized scratch than the administration of chlorpheniramine alone. There was a statistically significant improvement in the overall assessment of the patient's skin condition with the combined administration of chlorpheniramine + cimetidine. Chlorpheniramine given alone produced no significant benefit whilst cimetidine alone produced a marked exacerbation in itching in nearly half the patients who initially entered the study and was sufficient to require with‐drawal.