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Hyperglucagonaemia and necrolytic migratory erythema in cirrhosis—possible pseudoglucagonoma syndrome *
Author(s) -
DOYLE JOHN A.,
SCHROETER ARNOLD L.,
ROGERS ROY S.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb15104.x
Subject(s) - glucagonoma , medicine , glucagon , cirrhosis , occult , pancreas , erythema , autopsy , pathology , gastroenterology , dermatology , insulin , alternative medicine
SUMMARY Necrolytic migratory erythema is the distinctive cutaneous eruption seen with glucagon‐producing tumours of the pancreas. Recognition of this eruption is important because it may lead to the early diagnosis of a glucagonoma. Recently, we saw a patient who had necrolytic migratory erythema, hyperglucagonaemia, and cirrhosis of the liver with no evidence of pancreatic tumour while alive or at autopsy. Serum glucagon levels during the period of observation and during an oral glucose tolerance test suggested that the hyperglucagonaemia was not due to an occult glucagon‐producing tumour but may have been the result of advanced hepatic cirrhosis.