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The effect of various corticosteroids on the release of β‐glucuronidase from human leukocytes challenged with zymosan
Author(s) -
WATSON BRIAN,
RHODES E.L.,
MAJEWSKI B.B.J.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb15099.x
Subject(s) - zymosan , glucuronidase , chemistry , steroid , endocrinology , medicine , pharmacology , cortisone , corticosteroid , immunology , enzyme , biochemistry , hormone , in vitro
SUMMARY Seven corticosteroids were tested for their effect on the release of β‐glucuronidase when human white cells were challenged with zymosan. Stabilization was noted in two areas of dilution with every steroid but destabilization occurred at high concentrations. However, those steroids that stabilized effectively at low concentrations were also those which were the most potent vasoconstrictors.