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In vivo effect of UV‐B on lymphocyte function
Author(s) -
MORISON WARWICK L.,
PARRISH JOHN A.,
BLOCH KURT J.,
KRUGLER JOEL I.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb15094.x
Subject(s) - in vivo , lymphocyte , function (biology) , immunology , medicine , chemistry , biology , microbiology and biotechnology , genetics
SUMMARY Whole‐body exposure of normal subjects to erythemogenic doses of UV‐B radiation results in a decrease in the proportion of circulating E‐rosette‐forming lymphocytes, an increase in the proportion of null cells and a decreased incorporation of tridated thymidine into DNA of lymphocytes following stimulation by phytohaemagglutinin (PHA). These alterations are dose‐dependent, appear soon after exposure, reach a maximum after 8–12 h, and are reversed by 48–72 h post exposure.