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Histopathology of remodelling induced by PUVA in the superficial dermis
Author(s) -
PIERARD G.E.,
ACKERMAN A.B.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb06196.x
Subject(s) - dermis , psoriasis , epidermis (zoology) , histopathology , pathology , dermatology , fibrosis , puva therapy , medicine , anatomy
SUMMARY The histopathological alterations induced by PUVA within the skin are reported in a patient treated for psoriasis. The main impact is located at the site of former psoriatic plaques in which the target is the microvasculature. A residual coating sheath is present around vessels and fibrosis appears in the superficial dermis. These remodellings interfere with the normal dermo—epidermal relationships; the epidermis contains atypical keratinocytes, and melanocytes are no longer recognizable.