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Complement C3 and immunoglobulin in inflammatory acne vulgaris
Author(s) -
DAHL M.G.C.,
McGIBBON D.H.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb05641.x
Subject(s) - acne , inflammation , medicine , antibody , pathology , complement system , immunofluorescence , complement (music) , immunoglobulin m , immunology , immunoglobulin g , dermatology , biology , biochemistry , complementation , gene , phenotype
SUMMARY In patients with moderate to severe inflammatory acne, complement (C3) was detected by immunofluorescence in sixteen of sixteen early inflammatory acne lesions but in only one of thirteen biopsies of non‐inflamed skin from acne sites. C3 deposition occurred particularly in the walls of small dermal blood vessels and at the dermo‐epidermal junction. IgM was identified in vessel walls in four of sixteen early lesions. In eight late inflammatory lesions C3 deposition was much less prominent and was present in vessel walls in only two. None of the late lesions showed vascular deposition of IgM. The observations indicate that complement activation occurs in inflammatory acne and it is suggested that this may play a pathogenic role in the inflammation.