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Immune response to human keratoacanthoma
Author(s) -
FLANNERY G.R.,
MULLER H.K.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb05640.x
Subject(s) - keratoacanthoma , immunofluorescence , immune system , immunology , antibody , cytotoxicity , immunoglobulin g , medicine , complement dependent cytotoxicity , antibody dependent cell mediated cytotoxicity , biology , monoclonal antibody , pathology , in vitro , basal cell , biochemistry
SUMMARY Immune reactivity to human keratoacanthoma was investigated by microcytotoxicity tests and immunofluorescence. IgM and complement were consistently present in lesions; IgG and fibrin were infrequent. No evidence of in vivo bound immunoglobulin was found on the surface of keratoacanthoma cells by membrane immunofluorescence. Neither patients'sera nor peripheral blood leukocytes showed significant cytotoxicity against autochthonous tumour cells in microtitre assays. This study fails to support the view that regression of human keratoacanthoma is mediated by immunological mechanisms.