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A double‐blind trial of a zinc sulphate/citrate complex and tetracycline in the treatment of acne vulgaris
Author(s) -
CUNLIFFE W.J.,
BURKE B.,
DODMAN B.,
GOULD D.J.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb05626.x
Subject(s) - tetracycline , acne , medicine , dermatology , zinc , tetracycline hydrochloride , chemistry , antibiotics , biochemistry , organic chemistry
SUMMARY Forty‐eight patients participated in a 3‐month double‐blind study to compare the effect of orally administered zinc sulphate/citrate complex and tetracycline hydrochloride in acne vulgaris. Tetracycline significantly reduced the overall grade, and the number of non‐inflamed lesions, papules and pustules by the third month. It also reduced significantly the non‐inflamed lesions and papules at the end of the second month. In contrast, zinc therapy only had a significant effect on the pustules at the third month. The results indicate that tetracycline is far superior to the zinc complex in patients with moderately severe acne.