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Histological changes produced in skin by equally erythemogenic doses of UV‐A, UV‐B, UV‐C and UV‐A with psoralens
Author(s) -
ROSARIO REINALDO,
MARK GENE J.,
PARRISH JOHN A.,
MIHM MARTIN C.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb05623.x
Subject(s) - ultraviolet , dermatology , ultraviolet radiation , ultraviolet visible spectroscopy , medicine , chemistry , radiochemistry , physics , optics , organic chemistry
SUMMARY The sequential light microscopic histological changes produced in human skin by a single exposure of UV‐A, UV‐B, UV‐C and oral 8‐methoxypsoralen plus UV‐A (PUVA) causing approximately equal degrees of delayed erythema response, have been evaluated. UV‐C and UV‐B affect the epidermis to a greater degree than UV‐A, while UV‐A affects the dermis to a greater degree than UV‐B and UV‐C. PUVA has prominent effects on both epidermis and dermis, differing in degree from those changes induced by UV‐A, UV‐B, and UV‐C and are longer lasting. The sequence of histological changes following UV exposure is completed more rapidly after exposure to shorter UV wavelengths.