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8‐MOP plasma levels in PUVA problem cases with psoriasis
Author(s) -
WAGNER G.,
HOFMANN C.,
BUSCH U.,
SCHMID J.,
PLEWIG G.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb05621.x
Subject(s) - psoriasis , puva therapy , plasma levels , ingestion , medicine , gastroenterology , plasma concentration , dermatology
SUMMARY 8‐MOP plasma levels of psoriatic patients poorly responsive to PUVA treatment (PUVA problem cases) (N = 14) and of psoriatic patients with adequate response to photochemotherapy (N = 7) were measured for 8 h after oral ingestion of 0.6–0.8 mg/kg body weight, using a gas chromatographic method. We investigated whether there are any differences in the course of the plasma kinetics between the two groups. Problem patients showed significantly lower 8‐MOP plasma levels than the control group. Furthermore, the 8‐MOP plasma levels increased more rapidly in the control group than in these problem patients. Deviations in time of the maximum 8‐MOP plasma levels from the expected 2 h peak could be observed in 50%, of the problem cases compared to only 14%, of the control patients. There is no correlation between the dose and the 8‐MOP plasma level achieved in the two groups, i.e. higher doses do not result in higher levels. In individual cases there is not always a correlation between the plasma maximum of 8‐MOP at the time of UV‐A irradiation and the response to treatment. Adjustment of the UV‐A irradiation to coincide with the maximum plasma levels led to an improvement in therapeutic results for three problem patients.