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Dermatitis as a side‐effect of long‐term topical treatment with certain beta‐blocking agents
Author(s) -
JOOST TH.,
HUP J. MIDDELKAMP,
ROS F.E.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb05604.x
Subject(s) - blocking (statistics) , medicine , beta (programming language) , term (time) , dermatology , side effect (computer science) , pharmacology , physics , computer science , computer network , quantum mechanics , programming language
SUMMARY Three groups of glaucoma patients, treated topically with various beta‐blocking agents, were studied for mucocutaneous side‐effects of long‐term therapy. In five of eleven patients with ocular and/or periocular dermatitis as an adverse reaction to longterm treatment with metoprolol eye drops a dermatitis, reproducible by patch tests with pure metoprolol 3%, was demonstrable. Histopathological examination of positive patch tests examined in three cases showed a picture compatible with a delayed type of hypersensitivity. Four atenolol treated patients showed adverse reactions, but negative patch tests to atenolol were found. In addition new data are reported in favour of cross‐reactivity between certain beta‐blocking agents.