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The effects on epidermal DNA synthesis of topically applied cycloheximide
Author(s) -
MARSHALL ROBERT C.,
BROOKES LEONARD G.,
VIVIER ANTHONY
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb05602.x
Subject(s) - cycloheximide , in vivo , dna synthesis , pharmacology , toxicity , dna , thymidine , in vitro , chemistry , cytotoxic t cell , animal model , biology , biochemistry , protein biosynthesis , genetics , endocrinology , organic chemistry
SUMMARY An animal model for investigating topically applied epidermal cytotoxic drugs to determine optimum therapeutic doses and schedules is described. It is used here to examine the effects of cycloheximide on epidermal DNA synthesis, as measured by 3 H‐thymidine incorporation in vivo , in terms of dose/response and activity/time profiles and potential systemic toxicity.