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Disseminated intravascular coagulation associated with toxic epidermal necrolysis (Lyell's syndrome)
Author(s) -
KAVASNIČKA JAN,
ŘEZÁČ JAN,
ŠVEJDA JIŘÍ,
DUCHKOVÁ HANA,
KAZE FRANTIŠEK,
ŽALUD PAVEL,
RICHTER JOSEF
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb05580.x
Subject(s) - toxic epidermal necrolysis , disseminated intravascular coagulation , medicine , heparin , dermatology , intensive care unit , antibiotics , intensive care medicine , surgery , microbiology and biotechnology , biology
SUMMARY Evidence of disseminated intravascular coagulation was recorded in eight patients with toxic epidermal necrolysis (TEN)—Lyell's syndrome. Patients wee treated with low doses of heparin in combination with the usual treatment of TEN, i.e. maintenance of fluid and electrolyte balance, systemic corticosteroids, antibiotics and aseptic dressings, in the Intensive Care Unit environment. It is suggested that the alteration of haemostasis and inter‐related biological systems, such as activation of components of complement, kinins and immunoglobulins, may affect the outcome of TEN.