Hereditary angio‐oedema: treatment with danazol

SUMMARY An 8‐year‐old boy with hereditary angio‐oedema was treated with danazol under close endocrinological supervision. The boy's C1 esterase inhibitor (Clinh) and C4 levels increased rapidly to near normal values under a daily doses of 400 mg and were maintained at about 50% of the normal by maintenance doses of 200 mg danazol every other day. Throughout the entire treatment period (11 months) the boy has been maintained free from attacks of angio‐oedema. No hormonal imbalance was detected in the follow‐up period. Our results indicate that danazol should be suitable for the treatment of HAE not only in adults but also in prepubescent children.