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Studies on dapsone induced haemolytic anaemia
Author(s) -
MANFREDI GIULIANO,
PANFILIS GIUSEPPE,
ZAMPETTI MAURIZIO,
ALLEGRA FULVIO
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb01644.x
Subject(s) - dapsone , medicine , classics , humanities , history , art , dermatology
SUMMARY The present study was undertaken on the hypothesis that methaemoglobin production and haemolytic anaemia following dapsone administration could be ascribed to an impairment of glucose‐6‐phosphate dehydrogenase‐enzymatic activity. Analysis of the kinetic parameters of the G‐6‐PD (V max and K M ) was performed in ten patients, normal with respect to G‐6‐PD, suffering from various dermatoses. It was concluded that haemolytic anaemia after dapsone therapy is not due to a functional impairment of the enzyme. The close relationship between dapsone dosage, methaemoglobin production and anaemia make reasonable the hypothesis that a toxic dapsone derivative (DDS‐NHOH) could be responsible for the methaemoglobin formation and the haemolytic anaemia.