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Characterization of dermal collagen in systemic sclerosis
Author(s) -
LOVELL C.R.,
NICHOLLS A.C.,
DUANCE V.C.,
BAILEY A.J.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb01635.x
Subject(s) - dermis , thickening , pathology , epidermis (zoology) , staining , scleroderma (fungus) , medicine , type i collagen , chemistry , anatomy , polymer science , inoculation
SUMMARY The amount of dermal collagen is increased in systemic sclerosis. However, unlike certain inflammatory conditions, the relative proportions of Type I and Type III collagens are closely similar to those found in normal adult dermis. Similarly, no change in the distribution of the collagen types could be detected by immunofluorescent staining, although a considerable thickening of the epidermis was clearly evident in all the sclerotic lesions examined.