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Studies on the plasma membrane of normal and psoriatic keratinocytes
Author(s) -
GOMMANS J.M.,
BERGERS MIEKE,
ERP P.E.J.,
HURK JOSÉ J.M.A.,
MIER P.D.,
ROELFZEMA H.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb00018.x
Subject(s) - psoriasis , keratinocyte , microbiology and biotechnology , electron microscope , membrane , scanning electron microscope , chemistry , cell , biophysics , biology , pathology , medicine , immunology , biochemistry , optics , in vitro , physics
SUMMARY A method is described for the preparation of isolated keratinocytes suitable for subsequent biochemical studies. Scanning electron microscopy showed that the maturation process is accompanied by an increase in cell size and a shortening and eventual loss of microvilli. Psoriatic keratinocytes are distinguishable by exhibiting longer microvilli at all levels of maturation.