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Transient impairment of peripheral blood lymphocyte function during PUVA therapy
Author(s) -
MORISON WARWICK L.,
PARRISH JOHN A.,
BLOCH KURT J.,
KRUGLER JOEL I.
Publication year - 1979
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1979.tb00016.x
Subject(s) - puva therapy , transient (computer programming) , peripheral blood , medicine , peripheral , lymphocyte , immunology , psoriasis , computer science , operating system
SUMMARY Three parameters of immune function—enumeration of circulating T and B lymphocytes and response of lymphocytes to graduated doses of phytohaemagglutinin (PHA)—were examined serially in eleven patients with psoriasis before, during, and after an intensive course of PUVA therapy. A trend was detected for the lymphocyte response to PHA to fall during the first week of treatment and then rise back towards the pre‐treatment level. No alteration was found in the percentage or absolute numbers of circulating T and B lymphocytes. This study shows that routine PUVA therapy can induce an alteration in immune function but that this alteration is slight and short‐lived.