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Epidermal activity in the involved and uninvolved skin of patients with psoriasis
Author(s) -
MARKS R.
Publication year - 1978
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1978.tb06532.x
Subject(s) - psoriasis , dermatology , thymidine , medicine , pathology , chemistry , biochemistry , dna
SUMMARY A simple biochemical technique has been used to study the rate of incorporation of precursor materials in the involved and uninvolved skin of psoriatic subjects. Psoriatic plaques were found to incorporate tritiated thymidine twice as rapidly as skin from control subjects. The uninvolved skin of psoriatics showed a 48% increase in thymidine incorporation. Histidine and proline incorporations were also increased in psoriatic plaques but not in the uninvolved skin of psoriatics.