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Plasma cortisol values after topical application of diflucortolone valerate (0.3%) or clobetasol propionate (0.05%) in psoriatic patients
Author(s) -
KECZKES K.,
TEASDALE P.,
WISEMAN R.A.,
MUGGLESTONE C.J
Publication year - 1978
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1978.tb06180.x
Subject(s) - clobetasol propionate , medicine , valerate , psoriasis , dermatology , estradiol valerate , significant difference , chemistry , hormone , butyrate , food science , fermentation
SUMMARY A double‐blind randomized study to compare the plasma cortisol values at both 9.00 a.m. and 12 midnight following topical application of 10 g daily for 7days of either diflucortolone valerate 0.3% (Nerisone Forte) ointment or clobetasol propionate 0.05% (Dermovate) ointment in 20 hospital in patients suffering from sever psoriasis, showed that clinically both compounds behaved as potent, highly active topical preparations and caused rapid clinical improvement. Difllucortolone valerate 0.3% caused only slight and non‐significant depression of mean plasma cortisols. On the other hand clobetasol caused an immediate, persistent and statistically significant depression of the 9.00 a.m. cortisol values, which appeared to recover towards normality only on the third day after therapy had been withdrawn. The difference between these 2 compounds was found to be statistically significant ( P < 0.05). From these observations, it is concluded that diflucortolone valerate 0.3% ointment suppresses adreno‐cortical function to a significantly lesser extent than clobetasol propionate 0.05%, ointment.