Premium
Cellular fine structure in the invasive nodules of different histogenetic types of malignant melanoma
Author(s) -
HUNTER J.A.A.,
ZAYNOUN S.,
PATERSON W.D.,
BLEEHEN S.S.,
MACKIE RONA,
COCHRAN A.J.
Publication year - 1978
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1978.tb06152.x
Subject(s) - melanosome , melanoma , nodule (geology) , lentigo maligna , nodular melanoma , lentigo maligna melanoma , pathology , superficial spreading melanoma , ultrastructure , medicine , dermatology , biology , melanin , cancer research , paleontology , genetics
SUMMARY Ultrastructural studies were carried out on the invasive nodule of forty malignant melanomas. The findings support the concept that the fine structure of lentigo maligna melanoma is often characteristic, and differs from that of superficial spreading and nodular melanoma. The melanosomes in lentigo maligna melanoma are usually ellipsoidal and resemble those of normal melanocytes, whereas the melanosomes in superficial spreading and nodular melanoma are most often spheroidal and abnormal in appearance. Superficial spreading and nodular melanomas cannot be distinguished reliably by their ultrastructure. Melanosomal appearances could not be related to the presence of a pre‐existing naevus or the depth of invasion of the tumour nodule.