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Assessment of the skin penetration properties of different carrier vehicles for topically applied cortisol
Author(s) -
AYRES P. J. W.,
HOOPER G.
Publication year - 1978
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1978.tb02002.x
Subject(s) - penetration (warfare) , dorsum , steroid , hydrocortisone , chemistry , medicine , endocrinology , chromatography , anatomy , mathematics , hormone , operations research
SUMMARY Four commercially available topical preparations of cortisol, Alphaderm, Calmurid HC, Efcortelan and Topisone, had trace quantities of tritiated cortisol added to them. The resultant radiolabelled creams were applied to the dorsum of the pig and the penetration of the steroid was assessed. Alphaderm was shown to deliver ∼16.0 times more cortisol to the skin than Topisone, ∼8.0 times more than Efcortelan and ∼3.0 times more than Calmurid HC.